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Role of interleukin‐17 in acute myocardial infarction

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HighlightsHere we describe the role the interleukin‐17 in acute myocardial infarction.Interleukin (IL)‐17 affects several cells involved in the acute myocardial infarction.IL‐17 is involved in the pathogenesis of acute myocardial infarction.… Click to show full abstract

HighlightsHere we describe the role the interleukin‐17 in acute myocardial infarction.Interleukin (IL)‐17 affects several cells involved in the acute myocardial infarction.IL‐17 is involved in the pathogenesis of acute myocardial infarction. ABSTRACT Acute myocardial infarction (AMI) is a leading cause of death worldwide. Myocardial necrosis generates damage signals and triggers an intense inflammatory response. Many cytokines that contribute to repair tissue can also cause adverse left ventricular remodeling and heart failure. Several studies have revealed that interleukin‐17 (IL‐17) is a cytokine with a potential role in AMI. IL‐17 plays an important role in the immune response and affects the production of different inflammatory mediators in several types of cells, involved in the damage or scar process in myocardial tissue. In this review, we will discuss the current knowledge of the role of IL‐17 in AMI and the effect of IL‐17 in different cells, such as cardiomyocytes, smooth muscle cells and immune system cells, in AMI pathogenesis.

Keywords: acute myocardial; myocardial infarction; role interleukin; interleukin acute

Journal Title: Molecular Immunology
Year Published: 2019

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