LAUSR

Abstract This work aims at obtaining 2-hydroxypropyl-β-cyclodextrin inclusion complex with an original antiasthmatic compound in buffer solution and solid state with higher solubility and, hence, bioavailability. The compound solubility with different 2-hydroxypropyl-β-cyclodextrin concentrations has been studied by the phase solubility method. The linearity of the phase solubility diagrams is classified as an A L type and indicates the formation of inclusion complexes with 1:1 stoichiometry . The complex stoichiometry has been confirmed by the Job's method. The solubility of the studied compound in buffer has been considerably increased by complexation with 2-hydroxypropyl-β-cyclodextrin. Complexation stability constants and thermodynamic parameters have been calculated. The obtained inclusion complexes in solid state have been studied by the differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The kinetic characteristics of dissolution for the supramolecular complex have been obtained.