LAUSR

Abstract The article presents novel physicochemical data on C60(OH)24 aqueous solutions. Temperature and concentration dependencies of density (ρ) and speed of sound (u) and surface tension (γ) were obtained. Additionally, the study of human serum albumin (HSA) binding to C60(OH)24 fullerenol was conducted, and thermodynamic characteristics of C60(OH)24–HSA binding were calculated. The obtained values of a binding constant demonstrate that the complexes of C60(OH)24 with HSA are stable and HSA can perform transport functions in the bloodstream. Finally, excess thermodynamic functions of C60(OH)24–H2O binary system were calculated under the application of Virial Decomposition Asymmetric Model (VD-AS) and the boundaries of diffusion stability loss were determined. Aqueous solutions of C60(OH)20 are thermodynamically stable up to xdiff = 6.0 · 10−5. Further concentration increase leads to formation of third-order clusters with linear dimensions of thousands of nanometres and phase separation of the aqueous solution.