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Abstract The solubilization behavior and thermodynamics of fexofenadine.HCl in the binary mixtures of ethanol and water at temperature range of T = (293.2–313.2) K are investigated and the generated solubility data are… Click to show full abstract
Abstract The solubilization behavior and thermodynamics of fexofenadine.HCl in the binary mixtures of ethanol and water at temperature range of T = (293.2–313.2) K are investigated and the generated solubility data are mathematically represented by using four cosolvency models (i.e. van't Hoff equation, modified Wilson, Jouyban-Acree and Jouyban-Acree-van't Hoff models). The models performance is illustrated by mean relative deviations (MRD%). Based on the van't Hoff and Gibbs equations it is observed that the dissolution processes are endothermic and entropy-driven in every case.
Journal Title: Journal of Molecular Liquids
Year Published: 2021
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