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The thermal behavior of pyrazinamide in 12 solvents from 288.15 to 328.15 k

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Abstract The solubility of pyrazinamide in twelve pure solvents was measured from 288.15k to 328.15k.The experimental data were correlated by the modified Apelblat model, λh equation, Wilson model and NRTL… Click to show full abstract

Abstract The solubility of pyrazinamide in twelve pure solvents was measured from 288.15k to 328.15k.The experimental data were correlated by the modified Apelblat model, λh equation, Wilson model and NRTL model, and the modified Apelblat model gave the best satisfactory fitting results. These solubility data of pyrazinamide presented in this paper can provide the basis for the optimization of its crystallization and the preparation of its cocrystals.

Keywords: pyrazinamide; thermal behavior; pyrazinamide solvents; solvents 288; model; behavior pyrazinamide

Journal Title: Journal of Molecular Liquids
Year Published: 2021

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