LAUSR

Abstract The protein-surfactant interactions have been investigated for a long time due to their increased effectiveness in cleanliness and industrial processes. Moreover, Covid-19 outbreak has revolutionized the significance of protein-surfactant interactions, as soaps were proved the best cleansers and safe during this period. In this review article, an overview of physico-chemical aspects of protein-surfactant interactions along with various techniques has been discussed. In addition, the effect of different factors such as co-solvent, temperature, pH, chain length of surfactants, salt, and their impact on critical micelle concentration (CMC) of surfactant, structure, binding, thermodynamic parameters, and stability was also explained. This review will help the scientific community in understanding how to improve the effectiveness and applications of proteins and surfactants in pharmaceutical and other industries as protein-surfactant interactions can explain the significant phenomena of hydrophobic and electrostatic interactions.