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Boosting Antitumour Immunity through Targeted Delivery of Interferon-α.

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Immune checkpoint inhibitors (ICIs) have revolutionised cancer immunotherapy but their success is wholly dependent on amplifying an existing immune response directed against the tumour. A recent study by Tsuchiya et al.… Click to show full abstract

Immune checkpoint inhibitors (ICIs) have revolutionised cancer immunotherapy but their success is wholly dependent on amplifying an existing immune response directed against the tumour. A recent study by Tsuchiya et al. suggests how the properties of induced pluripotent stem cells (iPSCs) may be exploited for the targeted delivery of interferon-α (IFNα) to elicit an appropriate response.

Keywords: boosting antitumour; delivery interferon; targeted delivery; antitumour immunity

Journal Title: Trends in molecular medicine
Year Published: 2019

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