LAUSR

Abstract This work reports the profiles of drug release systems based on different polymers for the potential use as a skin anti-inflammatory. The materials used for the encapsulation of indomethacin were Pluronic P123 with various combinations of poly-ethylene-glycol and poly-N-vinyl pyrrolidone. These systems were characterized via Fourier transform infrared spectrometry and high resolution transmission electron microscopy. The morphology showed the treated polymers as spheres. Drug loadings were carried out via the absorption in solution method; this load was of a 1:10 wt ratio indomethacin to polymers. Drug release tests were performed via the dialysis method pH 7.2 phosphate buffered saline at 32 °C. The drug concentration was determined via UV–Vis spectroscopy, and additionally, a theoretical model was developed based on diffusion equations to describe the phenomenon. Comparison between the experimental results and theory was close to 5%.