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1,3,4-Thiadiazole-based diamides: Synthesis and complexation properties

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Abstract Aromatic diamides, derivative of 2,6-pyridinedicarboxylic acid and isophthalic acid, bearing 1,3,4-thiadiazole residue were prepared with satisfactory yields in conventional procedures and microwave stimulated reactions. X-ray structure of N,N′-bis(1,3,4-thiadiazol-2-yl)-2,6-pyridinedicarboxamide (2)… Click to show full abstract

Abstract Aromatic diamides, derivative of 2,6-pyridinedicarboxylic acid and isophthalic acid, bearing 1,3,4-thiadiazole residue were prepared with satisfactory yields in conventional procedures and microwave stimulated reactions. X-ray structure of N,N′-bis(1,3,4-thiadiazol-2-yl)-2,6-pyridinedicarboxamide (2) DMSO solvate (2·DMSO) was described. Selective zinc(II), lanthanum(III), terbium(III) and l -tyrosine recognition was found for N,N′-bis(1,3,4-thiadiazol-2-yl)-2,6-pyridinedicarboxamide in DMSO and its mixture with water. The IDA (Indicator Displacement Assay) system for metal cations sensing was proposed. The binding properties of 2 were compared with newly synthesized N,N′-bis(1,3,4-thiadiazol-2-yl)-1,3-benzenedicarboxamide 1.

Keywords: complexation properties; diamides synthesis; based diamides; synthesis complexation; bis thiadiazol; thiadiazole based

Journal Title: Journal of Molecular Structure
Year Published: 2017

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