Abstract Pyridine-2-(1H)-thiones were prepared by the reaction of the appropriate 1,3-diones with cyanothioacetamide. Based on DFT calculations, a molecular level understanding for this reaction mechanism gives for the first time… Click to show full abstract
Abstract Pyridine-2-(1H)-thiones were prepared by the reaction of the appropriate 1,3-diones with cyanothioacetamide. Based on DFT calculations, a molecular level understanding for this reaction mechanism gives for the first time a strong evidence for the preferential formation of one of the expected pyridinethione regioisomers. The latter compounds were utilized as intermediates for the synthesis of novel thieno[2,3-b]pyridines and bis(thieno[2,3-b]pyridines) via reaction with bromoacetylbenzofurans, bromoacetylbenzothiazole as well as the appropriate bis-bromoacetyl derivatives in ethanolic sodium ethoxide at reflux.
               
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