LAUSR

Abstract A new carrier platform was designed based on shellac wax-albumin for controlled drug delivery. For this purpose, human serum albumin (HSA) was immobilized on various amounts of shellac wax (W). Then, glutathione (G) and folic acid (F) were bounded to the albumin-wax at pH 7.4. doxorubicin (DOX) was loaded to wax, itself and modified wax systems in Tris buffer at pH 7.4 at a particle concentration range of 5–25 mg. The release studies of DOX from drug-loaded modified wax were performed by using buffers at various pH levels such as 2.2; 4.0; 6.0 and 7.4 of pH. The loading and release amounts of DOX were calculated by using fluorescence spectroscopy. Characterization of wax systems before and after DOX loading was done by using Fourier transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM) and Scanning electron microscopy (SEM) analysis. Polysaccharide based Controlled drug delivery system makes more bioavailable the pharmaceutical formulations in cancer therapy.