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Novel Benzimidazole- Platinum(II) Complexes: Synthesis, Characterization, Antimicrobial and Anticancer Activity

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Abstract Three new Platinum complexes (1-3) with 2,6-di-tert-butyl-4-(1-phenyl-1H-benzimidazol-2-yl) phenol (L1), N, N-dimethyl-4-(1-phenyl-1H-benzimidazol-2-yl) aniline (L2) and 4-(1H-benzimidazol-2-yl)-N, N-dimethylaniline (L3) were prepared and characterized by FT-IR, NMR and Elemental analyses. The crystal… Click to show full abstract

Abstract Three new Platinum complexes (1-3) with 2,6-di-tert-butyl-4-(1-phenyl-1H-benzimidazol-2-yl) phenol (L1), N, N-dimethyl-4-(1-phenyl-1H-benzimidazol-2-yl) aniline (L2) and 4-(1H-benzimidazol-2-yl)-N, N-dimethylaniline (L3) were prepared and characterized by FT-IR, NMR and Elemental analyses. The crystal structures of L1, 1 and geometrical isomer of 1 (1a) were determined by X-Ray crystallography. The cytotoxic activities of the compounds were tested on against SHSY-5Y and U-87 cell lines. The antimicrobial evaluations of the compounds showed that they have a moderate antimicrobial effect on gram positive and gram negative bacteria.

Keywords: platinum; complexes synthesis; benzimidazole platinum; novel benzimidazole; platinum complexes; synthesis characterization

Journal Title: Journal of Molecular Structure
Year Published: 2021

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