LAUSR

Abstract We have developed a perceptive and facile approach for the synthesis of new benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-one derivatives by one-pot two component condensation involving various o-phenylenediamines and substituted isatins in aqueous ethanol at 80 °C. In this methodology, the generation of C N bond and cleavage of C C bond have been conveniently established. This protocol furnishes an alternative route to synthesize benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-ones. The reaction provided good to excellent yields in a shorter reaction time and may be used for the easy generation of new, and bioactive benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-ones. Synthesized compounds were confirmed by their 1H NMR, 13C NMR, FT-IR and XRD.