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BACKGROUND The clinical spectrum of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease is expanding. OBJECTIVE To describe an unusual case of MOG-antibody-associated hypertrophic pachymeningitis (HP). METHODS Case study. RESULTS A 57-year-old female… Click to show full abstract
BACKGROUND The clinical spectrum of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease is expanding. OBJECTIVE To describe an unusual case of MOG-antibody-associated hypertrophic pachymeningitis (HP). METHODS Case study. RESULTS A 57-year-old female presented with a generalised seizure on a background of 3 months history of progressive cognitive decline and behavioural changes. Brain Magnetic Resonance Imaging (MRI) revealed widespread pachymeningeal enhancement and hyperintense signal in both hippocampi. Cerebrospinal Fluid (CSF) examination was normal. The patient was found positive for MOG-antibody. She clinically improved with steroids and the MRI abnormalities completely resolved. CONCLUSIONS Clinicians might consider testing for MOG-antibody in cases with HP.
Journal Title: Multiple sclerosis and related disorders
Year Published: 2020
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