LAUSR

BACKGROUNDS The interest about audiovestibular symptoms in patients with multiple sclerosis (MS) is recently growing. However, these symptoms can be often underestimated by patients. We aim to evaluate the presence of audiovestibular symptoms in patients with MS as reported by themselves and correlate these symptoms with the different phases of MS. Audiovestibular symptoms, if correlated with relapsing phase could be an indicator of disease progression. METHODS In this prospective study 80 patients with MS were screened for the presence of audiovestibular symptoms, during their first neurological consultation, using a self-administered questionnaire developed by our research team. Magnetic Resonance Imaging (MRI) scans were performed within a week from the consultation and were compared with scan performed 12-month before, looking for the presence of new active lesions or enlargement of the ones already present. Data on the year of diagnosis, symptom onset, treatment history and expanded disability status scale (EDSS) were collected. Statistical analysis was performed to identify a correlation between audiovestibular symptoms and active lesions in MRI scan. Odds ratio were calculated. RESULTS 75% of patients reported audiovestibular symptoms and 37.5% of them had an active or enlarged (compared with previous MRI) lesion/s in their brain MRI scan when they referred to the symptoms' presence. Active lesion/s in MRI were positively correlated with the presence of audiovestibular symptoms (p = 0.0009). Based on our analysis, patients with active lesions had an increased risk of developing audiovestibular symptoms compared to patients with enlarged but non-active lesions (odds ratio: 4.7). Lesions in the cortex rather than in the medulla (odds ratio: 0.6) or optic nerve (odds ratio:1.6), were more common in patients that developed audiovestibular symptoms. Patients with supratentorial active lesions were more at risk to present audiological symptoms than subjects with the infratentorial lesions (odd ratio: 1.3). CONCLUSIONS Audio-vestibular symptoms can arise in the relapsing phases of MS and their presence may be correlated with an active lesion in the brain. The self-administered questionnaire can be useful both for patients and physicians, to early identify the presence of audiovestibular symptoms that might be related to the progression of the disease.