LAUSR

&NA; Over the past decade there has been an enormous rise in the application of functional and structural connectivity approaches to explore the brain's intrinsic organization in healthy and clinical populations. The notion underlying the application of these approaches to study aging is that subtle age‐related disruption of the brain's regional integrity and information flow across the brain, are expressed by age‐related differences in functional and structural connectivity. In this review I will discus recent advances in our understanding of how age affects our brain's intrinsic organization, and I will share my perspective on potential challenges and future directions of the field. HighlightsOverall lower within‐ and higher between‐network connectivity in older adults.Less system segregation and lower “rich club” organization in older adults.Strong association between age‐effect on structural and functional connectivity.Age‐related connectivity changes appear to relate to cognitive decline.