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A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation

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Neurexins and neuroligins form trans-synaptic complexes that promote synapse development. In this issue of Neuron, Aricescu and colleagues (Elegheert et al., 2017) complement and strengthen two recent reports by the Kim… Click to show full abstract

Neurexins and neuroligins form trans-synaptic complexes that promote synapse development. In this issue of Neuron, Aricescu and colleagues (Elegheert et al., 2017) complement and strengthen two recent reports by the Kim and Rudenko teams (Kim et al., 2017; Gangwar et al., 2017) to dissect the molecular determinants by which MDGAs challenge the neurexin-neuroligin partnership.

Keywords: mdga interference; triad crystals; crystals sheds; light mdga; sheds light; interference neuroligation

Journal Title: Neuron
Year Published: 2017

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