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In this issue of Neuron, Joffe et al. (2020) assess the antidepressant-relevant effects and underlying neural mechanisms of negative allosteric modulators selective for either metabotropic glutamate receptors 2 (mGlu2) or 3… Click to show full abstract
In this issue of Neuron, Joffe et al. (2020) assess the antidepressant-relevant effects and underlying neural mechanisms of negative allosteric modulators selective for either metabotropic glutamate receptors 2 (mGlu2) or 3 (mGlu3). Negative modulation of both receptors enhanced excitatory glutamatergic input to mouse prefrontal cortex pyramidal cells, leading to antidepressant-relevant actions.
Keywords:
mechanisms group;
effects mechanisms;
negative allosteric;
allosteric modulators;
group mglu;
antidepressant effects
Journal Title: Neuron
Year Published: 2020
Link to full text (if available)
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Journal Title: Neuron
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!