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Locus revealed: Painlessness via loss of NaV1.7 at central terminals of sensory neurons

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How genetic loss of the sodium channel NaV1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, NaV1.7 channels at central terminals of pain-sensing… Click to show full abstract

How genetic loss of the sodium channel NaV1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, NaV1.7 channels at central terminals of pain-sensing afferents play a pivotal role in the balance between pain and analgesia.

Keywords: central terminals; locus revealed; via loss; revealed painlessness; painlessness via; loss

Journal Title: Neuron
Year Published: 2021

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