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DRD3-dependent plasticity within the VP drives subcircuit activity critical for cocaine seeking

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The ventral pallidum (VP) is a key hub within the reward system that mediates drug-seeking behaviors. However, molecular and cellular adaptations within the VP following drug use are not fully… Click to show full abstract

The ventral pallidum (VP) is a key hub within the reward system that mediates drug-seeking behaviors. However, molecular and cellular adaptations within the VP following drug use are not fully elucidated. In this issue of Neuron, Pribiag et al. (2021) demonstrate how cocaine induces circuit-specific changes within the VP via dopamine-receptor-D3-dependent processes to promote cocaine seeking.

Keywords: drd3 dependent; plasticity within; dependent plasticity; cocaine seeking; cocaine; within drives

Journal Title: Neuron
Year Published: 2021

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