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Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats

ABSTRACT Maternal sleep deprivation (MSD) has been suggested to be associated with increased frequency of neurodevelopmental disorders in offspring in both humans and animal models. However, the underlying cellular and… Click to show full abstract

ABSTRACT Maternal sleep deprivation (MSD) has been suggested to be associated with increased frequency of neurodevelopmental disorders in offspring in both humans and animal models. However, the underlying cellular and molecular mechanism is still unclear. We have recently reported that MSD at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal CA1 long‐term potentiation (LTP) in the offspring rats. Here, we report that the MSD induced LTP impairment at the CA1 hippocampus of the offspring rats is associated with increased long‐term depression (LTD) and reduced expression of postsynaptic GluA2‐containing &agr;‐amino‐3‐hydroxy‐5‐methyl‐isoxazole‐4‐propionic acid receptors (AMPARs). Importantly, we found that inhibition of AMPAR endocytosis by a synthetic peptide Tat‐GluA23Y (3 &mgr;mol/kg, i.p.) not only increased level of AMPARs and reduced LTD, but also restored LTP. Moreover, treatment with Tat‐GluA23Y peptide markedly alleviated the MSD‐induced impairments of spatial learning and memory; and decreased depressive‐ and anxiety‐like behaviors in the offspring. Together, our findings suggest that the MSD‐induced postsynaptic AMPAR endocytosis causally contributes to the impairments of hippocampal synaptic plasticity, thereby disrupting the emotional and cognitive functions in the offspring. HighlightsMSD induces synaptic and cognitive impairments in the offspring rats.MSD induces GluA2‐containing AMPAR endocytosis in the offspring rats.Tat‐GluA23Y peptide rescues synaptic and cognitive impairments in the offspring rats.

Keywords: sleep deprivation; ampar endocytosis; offspring rats; maternal sleep; induced impairments

Journal Title: Neuropharmacology
Year Published: 2018

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