LAUSR

ABSTRACT Learned associations between stimuli and responses make important contributions to priming. The current study aimed to determine whether medial temporal lobe (MTL) binding mechanisms mediate this learning. Prior studies implicating the MTL in stimulus‐response (S‐R) learning have not isolated associative learning at the response level from associative learning at other levels of representation (e.g., task sets or decisions). The current study investigated whether the MTL is specifically involved in associative learning at the response level by testing a group of amnesic patients with MTL damage on a priming paradigm that isolates associative learning at the response level. Patients demonstrated intact priming when associative learning was isolated to the stimulus‐response level. In contrast, their priming was reduced when associations between stimuli and more abstract representations (e.g., stimulus‐task or stimulus‐decision associations) could contribute to performance. These results provide novel neuropsychological evidence that S‐R contributions to priming can be supported by regions outside the MTL, and suggest that the MTL may play a critical role in linking stimuli to more abstract tasks or decisions during priming. HIGHLIGHTSLearned S‐R associations make important contributions to priming.Amnesic patients with MTL damage demonstrate intact S‐R learning during priming.MTL amnesics demonstrate impaired associative learning at more abstract levels.S‐R learning can be supported by regions outside the MTL.