LAUSR

Cortical inhibitory interneurons have a wide range of important functions, including balancing network excitation, enhancing spike-time precision of principal neurons, and synchronizing neural activity within and across brain regions. All these functions critically depend on the integration of synaptic inputs in their dendrites. But the sparse number of inhibitory cells, their small caliber dendrites, and the problem of cell-type identification, have prevented fast progress in analyzing their dendritic properties. Despite these challenges, recent advancements in electrophysiological, optical and molecular tools have opened the door for studying synaptic integration and dendritic computations in molecularly defined inhibitory interneurons. Accumulating evidence indicates that the biophysical properties of inhibitory neuron dendrites differ substantially from those of pyramidal neurons. In addition to the supralinear dendritic integration commonly observed in pyramidal neurons, interneuron dendrites can also integrate synaptic inputs in a linear or sublinear fashion. In this comprehensive review, we compare the dendritic biophysical properties of the three major classes of cortical inhibitory neurons and discuss how these cell type-specific properties may support their functions in the cortex.