LAUSR

&NA; When consolidated long‐term memories are reactivated they can destabilize, rendering the memory labile and vulnerable to modification. This period of lability is followed by reconsolidation, a process that restabilizes the memory trace. Reactivation‐induced memory destabilization is the gateway process to reconsolidation, but research in this area has focused primarily on the mechanisms underlying post‐reactivation restabilization. As a result, our understanding of processes subserving destabilization have lagged behind those responsible for reconsolidation. Here we review the literature investigating the neural basis of reactivation‐induced memory destabilization. We begin by reviewing memory destabilization broadly and the boundary conditions that influence the likelihood of reactivated memories to destabilize. We then discuss the fact that boundary conditions can be overcome in the presence of novelty, providing evidence for the theory that reconsolidation is a mechanism for memory updating. From here, we delve into a detailed review of the role of classical neurotransmitter systems, including dopamine, serotonin, noradrenaline, glutamate, GABA and acetylcholine, in reconsolidation, with a focus on their involvement in destabilization. Many of these neurotransmitters appear capable of promoting memory destabilization, and research investigating the cellular pathways through which they influence destabilization is a growing area. However, gaps remain in our understanding of how these neurotransmitters work in conjunction with one another to support destabilization across different types of memory and in different brain regions. Advances in the coming years within this research field should greatly contribute to our understanding of the neural mechanisms that influence the dynamic process of long‐term memory storage and modification, information crucial to the development of potential treatments for disorders characterized by strong, maladaptive memories.