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Abundant ghrelin gene expression by monocytes: Putative implications for fat accumulation and obesity

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Hormones encoded by the ghrelin gene, GHRL, regulate many body systems. Here, we show that GHRL is abundant in monocytes. Analysis of women subjected to bariatric surgery revealed a significant… Click to show full abstract

Hormones encoded by the ghrelin gene, GHRL, regulate many body systems. Here, we show that GHRL is abundant in monocytes. Analysis of women subjected to bariatric surgery revealed a significant postoperative reduction of GHRL in monocytes. We hypothesise that GHRL mediates monocyte-adipocyte cross-talk in health and obesity.

Keywords: abundant ghrelin; expression monocytes; gene expression; ghrelin gene; obesity

Journal Title: Obesity Medicine
Year Published: 2017

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