LAUSR

Abstract Aims Considering the protective role of adiponectin, we aimed to investigate the impact of different levels of adiponectin on biomarkers of inflammation among adolescents with obesity. Methods Were recruited 220 post-pubertal adolescents with obesity. Body composition, lipid profile, adiponectin and leptin concentrations were obtained. Adolescents were distributed in 3 groups (lower levels of adiponectin ≤4.85; medium levels of adiponectin >4.85 e ≤ 9.63; higher levels of adiponectin >9.63). GLM test was performed to analyze difference between groups with p level set at ≤0.05. Pathway analyze was performed. Results The most important find in the present low tertile has higher values of body fat compared to medium values. Interesting, insulin(μU/mL), HOMA –AD, total cholesterol (mg/dL), LDL, VLDL, Triglycerides (mg/dL), leptin and leptin/adiponectin ratio presented statistical higher values; inversely; QUICKI, HDL, and adiponectin/leptin ratio has lower when compared low with higher tertile. Analyzing the adiponectin pathway, the comportment of adiponectin was partially mediated by negative correlation with leptin/adiponectin ratio, HOMA-AD and HOMA-IR and positive correlation with HDL-col. Conclusion Together, these results may partly contribute to explain the role of adiponectin linking obesity whit atherosclerosis, as depended dose-response of this hormone concentration once in the lower tertile of adiponectin these results were not showed.