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Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause.

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This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The… Click to show full abstract

This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory results from major hormone therapy trials to date, evidence for the "timing hypothesis," and closes with recommendations for future research and for practicing clinicians.

Keywords: changes reproductive; aging perimenopause; cognitive changes; reproductive aging; perimenopause menopause

Journal Title: Obstetrics and gynecology clinics of North America
Year Published: 2018

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