LAUSR

s Committee: Chair: Kentaro Ikeda, DDS, MPH Co-Chair: Bhavik Desai, DMD, PhD #1: 11:00 Multifocal Granular Cell Tumors Occurring with Geographic Tongue *Saeed Arem, Richard Jordan, Caroline Shiboski, School of Dentistry University of California San Francisco, USA Background: Granular cell tumors occur in the oral cavity and other sites including the skin and are characterized by the accumulation of plump cells with granular cytoplasm. Often appearing yellow clinically, these tumors are benign, but may recur. Here we report a case of multiple GCTs occurring on the dorsum of the tongue of a 59-year-old woman who also had geographic tongue. Case summary: A 59-year-female, referred for evaluation of three masses in the middle of the tongue. The lesions were unchanged since initial presentation two weeks earlier and no treatment had been rendered. The patient reported a burning sensation in the anterior half of tongue that preceded the lesions. Past medical, family, social, and dental history were unremarkable. Intraoral examination revealed three round, well-defined nodules with normal overlying mucosa located right of midline of the anterior portion of the tongue, firm to palpation and measuring each 1 x 1cm, 4 x 4mm, and 2 x 3mm, respectively. The patient’s tongue also showed depapillated areas surrounded by white rims. Differential diagnoses for the nodules included GCT and lipoma. Diagnoses of geographic tongue and fungal overgrowth were also made. An antifungal was prescribed, and one week later excisional biopsies were performed of the masses. The tumor cells were S-100 and NKI-C3 positive but negative for MiTF confirming the diagnosis of GCT. Conclusions: GCTs are typically solitary asymptomatic yellowish nodules. This case is unusual because of the multifocal presentation, mucosal color, and burning pain, which was explained by concurrent geographic tongue.