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Organism and Microbiome Analysis: Techniques and Implications for Chronic Rhinosinusitis.

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Modern advances in DNA sequencing have allowed for the development of culture-independent techniques with application to infectious and inflammatory conditions, such as rhinosinusitis. Although paradigm-changing discoveries have resulted from molecular… Click to show full abstract

Modern advances in DNA sequencing have allowed for the development of culture-independent techniques with application to infectious and inflammatory conditions, such as rhinosinusitis. Although paradigm-changing discoveries have resulted from molecular microbiologic methods for a number of diseases, insights provided into the role of bacteria in chronic rhinosinusitis have yet to be fully understood to the point of impacting clinical diagnosis and management. As culture-independent techniques continue to evolve and become more refined, it is likely that a better understanding will emerge of how the microbiome influences chronic rhinosinusitis pathogenesis and response to therapy.

Keywords: analysis techniques; rhinosinusitis; chronic rhinosinusitis; microbiome analysis; techniques implications; organism microbiome

Journal Title: Otolaryngologic clinics of North America
Year Published: 2017

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