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Otosclerosis: From Genetics to Molecular Biology.

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Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis… Click to show full abstract

Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.

Keywords: genetics molecular; otosclerosis; biology; molecular biology; otosclerosis genetics

Journal Title: Otolaryngologic clinics of North America
Year Published: 2018

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