LAUSR

Haemoglobinopathy Screening .................................................................................. 1 Aim 2 1. Background information ....................................................................................... 2 Thalassaemia ................................................................................................................ 2 Sickle cell disease .......................................................................................................... 3 2. Geographical Distribution of Haemoglobin Disorders .......................................... 3 Populations at risk of Haemoglobin Disorders ................................................................ 3 3. Effect of Thalassaemia Types in Pregnancy ........................................................ 4 4. Effect of Sickle Cell in Pregnancy ........................................................................ 5 5. Screening Women for Haemoglobin Disorders ................................................... 5 5.1 Screening and Referral Process........................................................................... 5 5.2 Women with no identified risk factors for haemoglobinopathy .............................. 6 5.3 Women who are at risk of Haemoglobinopathy Disorders .................................... 6 5.4 Obtaining Partner Haemoglobin Studies .............................................................. 7 5.5 Assessing the Fetus at Risk ................................................................................. 7 5.6 Women and current partners who have been screened in previous pregnancies 8 5.7 Partners who decline ‘paternal’ testing/partner no longer in contact with woman or unknown .......................................................................................................... 8 5.8 Women referred to KEMH for Haemoglobinopathy Screening ............................. 9 5.9 Women who attend KEMH in early pregnancy/non pregnant with suspected or confirmed haemoglobin disorder .......................................................................... 9 6. Management of Co-Existing Iron Deficiency .......................................................... 9 Screening Women for Haemoglobin Disorders: Flow chart ...................................... 11 Significant maternal haemoglobinopathies requiring referral and obstetric management by the Department of Fetal Medicine, King Edward Memorial Hospital12 No Fetal Risk of Fetal Hb Disease; sign of by the CNC Haematology ..................... 13 References and resources ....................................................................................... 14 CLINICAL PRACTICE GUIDELINE