LAUSR

BACKGROUND There is still no systematized evidence in the literature regarding the combination of curcumin to improve the effects of antimicrobial photodynamic therapy (aPDT) on complex oral biofilms. Therefore, the objective of this review was to systematically assess the antimicrobial effect of curcumin-mediated aPDT on the vitality of biofilms of microorganisms Streptococcus mutans and Candida albicans. METHODS The addressed focused question was: "What are the effects of curcumin-mediated antimicrobial therapy on the biofilm viability of Streptococcus mutans and Candida albicans in vitro models?" A literature search was conducted in the electronic databases Pubmed, Web of Science, Scopus, Cochrane Library and Bireme up to April 2019. In vitro studies evaluating the effect of curcumin-mediated antimicrobial photodynamic therapy on S. mutans and C. albicans biofilms were included. RESULTS From 95 citations, 11 full-text articles were screened and 6 studies were included in this review. Because of the heterogeneity observed in the studies selected, meta-analysis was not possible. CONCLUSIONS The in vitro studies indicate the potential use of curcumin-mediated aPDT to inactivate microorganisms Streptococcus mutans and Candida albicans. The aftereffects of this survey ought to be viewed as starter and further in-vitro ponders with institutionalized laser parameters are expected to get solid ends.