LAUSR

Penile intraepithelial neoplasia(PIN)is a premalignant lesion that can affect any part of the penile surface. Approximately 10-30% of PIN patients are at risk of progression to squamous cell carcinoma (SCC), with metastatic potential of 3% to 5% after progression to aggressive malignancy. The use of photodynamic therapy (PDT) for PIN is currently controversial. Here, we performed circumcision in combination with PDT and successfully cured 3 cases of PIN. We considered that circumcision is very important before PDT. We recommend the treatment of circumcision combined with PDT to treat for the patients with PIN, especially for the patients who have failed to previous treatment, or with an excessively long foreskin.