LAUSR

Abstract Evidence suggests that enhanced oxidative stress and mild, chronic inflammation is associated with the onset and progression of some neurological disorders. Hypothesis: A polyphenol rich sugarcane extract may be active in protecting against this inflammation and neurological degeneration. Study design: A series of cell culture strains and in vitro gene expression studies were used to understand the neuroprotective activity. Methods: Extract was prepared according to a patented extraction process and dose responses for TNF-α inhibition, Nrf-2 activation, MAO inhibition, DNA damage marker and AChE inhibition were prepared. This was in addition to a gene array assay for 84 genes related to neurogenesis. Results: PRSE displayed anti-inflammatory effect, possibly through inhibiting pro-inflammatory cytokines and activating Nrf2-ARE transcription pathway, and may exert neurological benefits through suppressing neuro-inflammation. In particular, subsequent studies with neuronal cells indicate that PRSE may exert additional neurological benefits through promoting genes that encode neurogenesis-related growth factors and regulate neuronal differentiation, preserving neuronal DNA from oxidative stress damage, and inhibiting key neuronal therapeutic targets such as MAO and AChE as a pathway to attenuate oxidative stress Conclusion: We report promising preclinical studies for the therapeutic intervention of a new polyphenol rich sugarcane extract on inflammation and neurological disorder modulation.