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Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity.

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Seven undescribed cycloartane triterpenoids, pseudolarnoids A-G, together with ten known ones, were isolated from the seeds of Pseudolarix amabilis (J. Nelson) Rehder. Their structures were elucidated on the basis of… Click to show full abstract

Seven undescribed cycloartane triterpenoids, pseudolarnoids A-G, together with ten known ones, were isolated from the seeds of Pseudolarix amabilis (J. Nelson) Rehder. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography, and ECD data. Pseudolarnoids A-C are cycloartane triterpenoids with a unique 16S, 23R-spirolactone moiety. Pseudolarnoids F, G, and pseudolarolide C demonstrated potent antiviral effects on HSV-1 in vitro.

Keywords: pseudolarix amabilis; antiviral activity; cycloartane; triterpenoids pseudolarix; cycloartane triterpenoids; amabilis antiviral

Journal Title: Phytochemistry
Year Published: 2020

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