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Twenty-five steroidal glycosides including eight undescribed compounds which were named as polygonatumosides H-O, were isolated from the 70 % EtOH extract of rhizomes of Polygonatum odoratum (Mill.) Druce (Asparagaceae). Their structures… Click to show full abstract
Twenty-five steroidal glycosides including eight undescribed compounds which were named as polygonatumosides H-O, were isolated from the 70 % EtOH extract of rhizomes of Polygonatum odoratum (Mill.) Druce (Asparagaceae). Their structures were elucidated by extensive spectroscopic analyses and chemical methods. The isolated compounds were evaluated cytotoxicity against three human cancer cell lines: human non-small cell lung cancer (A549), human epithelial colorectal adenocarcinoma (Caco2), and human hepatocellular carcinoma (HepG2) cells. Five compounds showed cytotoxicity against these cell lines with IC50 values in the range of 1.7-30.8 μM.
Journal Title: Phytochemistry
Year Published: 2021
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