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Abstract Peniopyranone ( 1 ) and 2-methoxyl- β - l -Arabinofuroside uracil ( 2 ), together with six known compounds were isolated from the broth of Penicillium sp. (NO. 64).… Click to show full abstract
Abstract Peniopyranone ( 1 ) and 2-methoxyl- β - l -Arabinofuroside uracil ( 2 ), together with six known compounds were isolated from the broth of Penicillium sp. (NO. 64). And their structures were established by comprehensive analysis of NMR, MS and CD spectra, the absolute configurations of Peniopyranone ( 1 ) were determined as 7 S , 8 S and 9 R by calculating its ECD. The eight obtained metabolites were subjected to evaluate the preliminary cytotoxic activities to four cancer cell lines, but they showed no significant data with IC 50 > 50 μmol/mL. The results of acetylcholinesterase inhibiting assay showed that peniopyranone ( 1 ) displayed the inhibition activity to acetylcholinesterase with IC 50 at 15.2 μmol/mL.
Journal Title: Phytochemistry Letters
Year Published: 2017
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