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Abstract Four new farnesylated isoindolinone derivatives, named stachybotrysams A–D ( 2 – 5 ), and one new farnesyl-cyclized analogue, named stachybotrysam E ( 6 ), as well as one known… Click to show full abstract
Abstract Four new farnesylated isoindolinone derivatives, named stachybotrysams A–D ( 2 – 5 ), and one new farnesyl-cyclized analogue, named stachybotrysam E ( 6 ), as well as one known congener ( 1 ), were isolated from the filamentous fungus Stachybotrys chartarum CGMCC 3.5365. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and by comparison with reported data. Compounds 2–4 exhibited significant HIV-inhibitory activity with IC 50 values of 9.3, 1.0, and 9.6 μ M, respectively.
Keywords:
fungus stachybotrys;
isoindolinone derivatives;
stachybotrys chartarum
Journal Title: Phytochemistry Letters
Year Published: 2017
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Journal Title: Phytochemistry Letters
Year Published: 2017
Link to full text (if available)
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recommendations!