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Prenylated xanthones from the stem bark of Garcinia dulcis

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Abstract Three new prenylated xanthones, named dulcisxanthone J ( 1 ), dulcisxanthone K ( 2 ), and dulcisxanthone L ( 3 ), along with 38 known compounds have been isolated… Click to show full abstract

Abstract Three new prenylated xanthones, named dulcisxanthone J ( 1 ), dulcisxanthone K ( 2 ), and dulcisxanthone L ( 3 ), along with 38 known compounds have been isolated from the stem bark of Garcinia dulcis . Their structures were elucidated mainly by analysis of 1D and 2D spectroscopic data. 12b-Hydroxy-des-D-garcigerrin A (12) and dulcisxanthone J ( 1 ) displayed moderate antibacterial activity against both penicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) with minimum inhibitory concentration (MIC) values of 4 and 16 μg/mL, respectively.

Keywords: dulcisxanthone; stem bark; prenylated xanthones; bark garcinia; garcinia dulcis

Journal Title: Phytochemistry Letters
Year Published: 2017

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