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Abstract Four new C19-diterpenoid alkaloids, named taronenines A-D (1-4), have been isolated from the roots of Aconitum taronense Fletcher et Lauener (Ranunculaceae), which has long been used as a folk… Click to show full abstract
Abstract Four new C19-diterpenoid alkaloids, named taronenines A-D (1-4), have been isolated from the roots of Aconitum taronense Fletcher et Lauener (Ranunculaceae), which has long been used as a folk medicine to treat rheumatism and arthritis in China. Their structures were established on the basis of extensive spectroscopic analyses. The isolated compounds were evaluated for their potential anti-inflammatory effects using LPS-stimulated RAW 264.7 macrophages. Compounds 1, 2 and 4 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 29.60 ± 0.08 μg/mL, 18.87 ± 0.14 μg/mL, and 25.39 ± 0.11 μg/mL, respectively.
Journal Title: Phytochemistry Letters
Year Published: 2018
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