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Fomitopsins I and J, 24-methyl-lanostane triterpenoids from fruiting bodies of the wood-rot basidiomycete Fomitopsis sp.

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Abstract Two new 24-methyl-lanostane triterpenoids, fomitopsins I (1) and J (2), were isolated together with seven known compounds (3–9), from fruiting bodies of the basidiomycete Fomitopsis species. The structures were… Click to show full abstract

Abstract Two new 24-methyl-lanostane triterpenoids, fomitopsins I (1) and J (2), were isolated together with seven known compounds (3–9), from fruiting bodies of the basidiomycete Fomitopsis species. The structures were elucidated by spectroscopic analysis. Their antibacterial and cytotoxic activities were evaluated. One of the known compounds (6) exhibited antibacterial activity against Gram-positive bacteria, Bacillus cereus (MIC 6.25 μg/ml) and Enterococcus faecium (MIC 12.5 μg/ml).

Keywords: lanostane triterpenoids; fomitopsins methyl; basidiomycete fomitopsis; fruiting bodies; methyl lanostane

Journal Title: Phytochemistry Letters
Year Published: 2019

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