LAUSR

Abstract Myrothecol A (1), a rare 10,13-cyclo macrocyclic trichothecene, and two known compounds (2 and 3) were isolated from the fungus Myrothecium roridum, which was obtained from the gut of a locust Atractomorpha sinensis Bolivar. Their structures and absolute configurations were determined through HRESIMS (high resolution electrospray ionization mass spectroscopy), NMR (nuclear magnetic resonance), ECD (electronic circular dichroism), and Mo2(OCOCH3)4-induced ECD experiments. Compounds 1−3 exhibited potent cytotoxic effects against human tumor cell lines MGC803 and NCI-H1975 with IC50 values between 68 nM and 28.72 μM. These results suggested that macrocyclic trichothecenes could be a kind of potential precursors for the anti-cancer drug development.