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Computational models and fundamental constraints can inform the design of synthetic connectomes: Comment on "What would a synthetic connectome look like?" by Ithai Rabinowitch.

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Abstract Rabinowitch's article [1] offers an outline of synthetic connectomics where, in analogy to synthetic biology, connectomes are constructed. Rather than building connectomes in a computer model, say by observing… Click to show full abstract

Abstract Rabinowitch's article [1] offers an outline of synthetic connectomics where, in analogy to synthetic biology, connectomes are constructed. Rather than building connectomes in a computer model, say by observing artificial neural networks, the idea is to build in vivo biological connectomes. By building connectomes from scratch this proposal is different from approaches that aim to modify already existing connectomes found in animals or humans. However, there are constraints, technical limitations, and competing approaches that will need to be considered when building connectomes.

Keywords: constraints inform; inform design; models fundamental; fundamental constraints; computational models; building connectomes

Journal Title: Physics of life reviews
Year Published: 2019

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