LAUSR

Abstract Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane.