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Platelet dysfunction during pediatric cardiac ECMO

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Abstract Pediatric extracorporeal membrane oxygenation (ECMO) is used for respiratory and cardiac failure refractory to conventional treatment. ECMO has been increasingly utilized for pediatric cardiac patients. Despite improved mortality, complications… Click to show full abstract

Abstract Pediatric extracorporeal membrane oxygenation (ECMO) is used for respiratory and cardiac failure refractory to conventional treatment. ECMO has been increasingly utilized for pediatric cardiac patients. Despite improved mortality, complications during and after ECMO are high and bleeding may be life threatening. Pediatric cardiac patients are at high risk for bleeding due to anticoagulation, surgery, and acquired platelet dysfunction. In this review, we focus on the many mechanisms contributing to platelet dysfunction, available monitoring of platelet function, what is known about platelet count and transfusion, treatment of bleeding, and future steps needed to improve our care for this patient population.

Keywords: dysfunction pediatric; ecmo; platelet dysfunction; pediatric cardiac; platelet

Journal Title: Progress in Pediatric Cardiology
Year Published: 2020

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