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Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry.

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Proliferation of malaria parasites in a host requires mechanisms to spread between red blood cells (RBCs). We discuss here the implications for biology and antimalarial drug development of companion studies… Click to show full abstract

Proliferation of malaria parasites in a host requires mechanisms to spread between red blood cells (RBCs). We discuss here the implications for biology and antimalarial drug development of companion studies that establish the requirement of two Plasmodium spp. proteases of the plasmepsin family in parasite egress from, and invasion into, RBCs.

Keywords: malaria parasite; plasmodium proteases; block malaria; plasmodium; proteases block; targeting plasmodium

Journal Title: Trends in parasitology
Year Published: 2018

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