LAUSR

Background The mortality of the COVID-19 pandemic is high and data regarding its prognosis is scarce. We aimed to assess the survival experience and determining factors in adult inpatients with laboratory-confirmed COVID-19. Methods We conducted a nationwide and retrospective cohort study. Data from 66,123 individuals were analyzed using the Kaplan-Meier method and a multivariate Cox proportional hazard regression model was fitted. Results The 7-day survival was 72.2% and went to 47.6%, 35.0%, and 23.9% on days 15, 21, and 30 of hospital stay, respectively. In the multiple analysis, factors associated with an increased risk of dying were male gender, age, pneumonia at hospital admission, immunosuppression and personal history of chronic non-communicable diseases. Reduced risk of a fatal outcome was observed among patients with asthma history. Conclusions To the best of our knowledge, this is the largest study analyzing the survival probability in a large subset of Latin-American adults with COVID-19, in whom the disease burden has been high. Our results contribute to achieving a better understanding of disease evolution.