LAUSR

ABSTRACT Research question : Is there a relationship between endometriosis and placenta previa (PP)? Design To investigate if there is a relationship between endometriosis and PP a retrospective study was carried out, using prospectively recorded data from two different data-bases from Cruces University Hospital. Two different populations were included in the study. The ART (assisted reproduction techniques) population consisted of 246 cesarean sections (CS), from a total of 1170 deliveries, all of them resulting from ART and the Obstetrics population consisted of 7045 CS, from a total of 50298 deliveries. A representative subset was established selecting 4 CS without endometriosis for each CS with endometriosis. Results In our ART population, the PP rate was 1.71% among all deliveries and 8.13% among CS. In our general obstetric population, the PP rate was 0.34% among all deliveries and 2.41% among the CS. Among the CS in ART pregnancies, the PP rate was 20% in the women with endometriosis vs 5.47% in the other women (OR= 4.32; 95% CI =1.67- 11.17), while considering all ART deliveries, the PP rates were 6.43% and 1.07% respectively (OR= 6.36; 95% CI= 2.59-15.65). In the CS-Obstetrics population, the rate of PP was 12.05% among women with endometriosis vs 2.73% among women without endometriosis (OR = 4.89; 95% CI=2. 52- 9. 47). Considering all deliveries, the PP rate was 1.35% among women with endometriosis vs 0.2% in other women. Differences persisted when adjusting for age, IVF, multiplicity and previous deliveries. Conclusion(s) Endometriosis is associated with a higher risk of PP even after adjusting for other parameters.