LAUSR

ABSTRACT Research question : Does the sex of reciprocal translocation carriers affect meiotic segregation patterns and stability of non-translocated chromosomes during meiosis? Design : A total of 790 couples who underwent preimplantation genetic testing for reciprocal translocations by using the single nucleotide polymorphism (SNP) array platform from October 2016 to December 2019 were included. Among them, 294 couples had their euploid embryos distinguished between normal euploidies and balanced translocation carriers. Results : Female translocation carriers had a significantly lower incidence of alternate segregation pattern than male carriers (43.26% vs. 47.98%, P = 0.001), but a higher incidence of 3:1 segregation pattern (6.70% vs. 4.29%, P Conclusion : The sex of the translocation carriers impacted meiotic segregation patterns with no effect on the stability of non-translocated chromosomes during meiosis.