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When to rule out COVID-19: How many negative RT-PCR tests are needed?

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Abstract Amidst the COVID-19 pandemic, clinicians have been plagued with dilemmas related to the uncertainty about diagnostic testing for the virus. It has become commonplace for a patient under investigation… Click to show full abstract

Abstract Amidst the COVID-19 pandemic, clinicians have been plagued with dilemmas related to the uncertainty about diagnostic testing for the virus. It has become commonplace for a patient under investigation (PUI) to repeatedly test negative but have imaging findings that are consistent with COVID-19. This raises the question of when the treating team should entertain alternative diagnoses. We present such a case to help provide a framework for how to weigh repeatedly negative test results in clinical decision making when there is ongoing concern for COVID-19.

Keywords: many negative; pcr tests; negative pcr; tests needed; covid many; rule covid

Journal Title: Respiratory Medicine Case Reports
Year Published: 2020

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